Sunday, March 15, 2020 Location: Maryland Ballroom – D
4:00 pm
Opening Remarks Darryl C. Zeldin, MD, NIH/NIEHS, Research Triangle Park, NC
SESSION I: IN MEMORY OF JOHN A. OATES
Co-Chairs:
Nancy J. Brown, M.D., Vanderbilt University, Nashville, TN Lawrence Marnett, Ph.D., Vanderbilt University, Nashville, TN
4:05 pm
Drs.Brown/Marnett
Tribute to Dr. Oates.
4:20 pm
Garret A. FitzGerald, MD, University of Pennsylvania, Philadelphia, PA
Prostaglandins and their Inhibitors: The Legacy of John Oates.
4:45 pm
James M. Luther, MD, Vanderbilt University School of Medicine, Nashville, TN
TBA.
5:10 pm
Darryl C. Zeldin, MD, NIH/NIEHS, Research Triangle Park, NC
Biochemical Regulation of EET Formation and Hydrolysis: Following on the Legacy of John Oates.
5:35 pm
Coffee Break (20 min)
SESSION I: PROLM YOUNG INVESTIGATORS SESSION (SPONSORED BY ELSEVIER/PROSTAGLANDINS AND OTHER LIPID MEDIATORS)
Co-Chairs:
To be named
5:55 pm
Speaker
Introduction of Young Investigator Session
6:00 pm
Victoria Hallisey, Beth Israel Deaconess Medical Center, Boston, MA
TBA
6:15 pm
Wojciech Jankiewicz, Medical College of Wisconsin, Milwaukee, WI
TBA
6:30 pm
Xi Lan, Johns Hopkins School of Medicine, Baltimore, MD
TBA
6:45 pm
Fumie Nakashima, Vanderbilt University Medical Center, Nashville, TN
TBA
7:00 pm
Welcome Reception/Meet the Exhibitors
Maryland Ballroom Foyer
MONDAY, MARCH 16, 2020
7:15-8:15 am
Trainee Roundtable: Homeland Room
ORAL PRESENTATIONS
Location: Maryland Ballroom – D SESSION III: ROLE OF LIPID MEDIATORS IN THE RESOLUTION OF INFLAMMATION
Co-Chairs:
Dipak Panigrahy, M.D., Beth Israel Deaconess Medical Center
Gabrielle Fredman, Ph.D., Albany Medical College, Albany, NY
8:30 am
Gabrielle Fredman, Ph.D., Albany Medical College, Albany, NY
TBA
8:55 am
Niccolò Terrando, B.Sc. (hons), D.I.C., Ph.D., Duke University Medical Center, Durham, NC
Resolution of Neuroinflammation in Postoperative Delirium.
9:20 am
John L. Wallace, Ph.D., MBA, University of Calgary & Antibe Therapeutics Inc, Toronto, Ontario, Canada
Toward Safer and More Effective Analgesics: Clinical Trials of H2S-Releasing Drugs
9:45 am
Thomas E. Van Dyke, DDS, Ph.D., Forsyth Institute/Harvard Faculty of Medicine, Cambridge, MA
Resolution of Oral Inflammation
10:10 am
Stephen P. Chelko, Ph.D., Johns Hopkins School of Medicine, Baltimore, MD
Therapeutic Targeting of Myocardial Inflammation in Arrhythmogenic Cardiomyopathy
10:35 am
Coffee Break (20 min)
Session IV: LIPIDOMICS ANALYSIS OF OXYLIPINS IN BIOLOGICAL AND CLINICAL SAMPLES
Co-Chairs:
Nils Helge Schebb, Ph.D., University of Wuppertal, Wuppertal, Germany Co-Chair to be named
10:55 am
Edward A. Dennis, Ph.D., University of California-San Diego, CA
Plasma Lipidomic Profiling in Nonalcoholic Steatohepatits (NASH)
11:20 am
John W. Newman, Ph.D., University of California, Davis, CA
Pre-analytical Considerations for Bio-banked Plasma and/or Serum Lipid Mediator Investigations
11:45 am
Nicole M. Hartung, University of Wuppertal, Germany
Oxylipin Analysis – Strategies to Ensure Comparable and Reproducible Results
12:00 pm
Christopher Ramsden, M.D., National Institute on Aging, Bethesda, MD
Analysis of Oxylipins in Serum and Plasma following Controlled Dietary Manipulation in Patients with Chronic Headaches; Challenges and Interpretation
12:20 pm
Mathew L. Edin, Ph.D., National Institute of Environmental Health & Safety, RTP, NC
Regulation of Oxylipins in Carriers of CYP2J2*7 and EPHX2 K55R Polymorphisms
12:40 pm
Lunch Break (1 hr, 20 min)
SESSION V: NOVEL INSIGHTS IN CANCER AND EICOSANOIDS
Co-Chairs:
Paola Patrignani, Ph.D., “G. d’Annunzio” University, Chieti, Italy
Dieter Steinhilber, Ph.D., University of Frankfurt, Frankfurt, Germany
2:00 pm
Paola Patrignani, Ph.D., “G. d’Annunzio” University, Chieti, Italy
Cancer Development and Progression and its Relation to Platelets
2:25 pm
Dieter Steinhilber, Ph.D., Goethe University Frankfurt, Frankfurt, Germany
Beyond Leukotriene Formation – The Noncanonical Functions of 5-Lipoxygenase
2:50 pm
David A. Potter, M.D., Ph.D., University of Minnesota, Minneapolis, MN
Novel Insights into the Role of CYP Monooxygenases in Tumor Progression
3:15 pm
Emanuela Ricciotti, Ph.D., University of Pennsylvania, Philadelphia, PA
NSAID-gut Microbiota Interactions: Implications for Cancer Treatment
3:40 pm
Coffee Break (20 min)
SESSION VI: GI TRACT (COLON, LIVER, PANCREAS) AND OTHER TISSUES – INFLAMMATION/METABOLIC
Co-Chairs:
Guodong Zhang, Ph.D., University of Massachusetts, Amherst, MA
Tara M. Nordgren, Ph.D., University of California, Riverside, CA
4:00 pm
Tara M. Nordgren, Ph.D., University of California, Riverside, CA
Maresin-1-mediated Protection from Dust-induced Lung Inflammation is Associated with Enhanced Macrophage IL-22 Signaling
4:25 pm
Guodong Zhang, Ph.D., University of Massachusetts, Amherst, MA
Soluble Epoxide Hydrolase is an Endogenous Regulator of Obesity-induced Intestinal Barrier Dysfunction and Bacterial Translocation
4:50 pm
Imad Shureiqi, M.D., University of Texas MD Anderson Cancer Center, Houston, TX
PPARD, Metabolism and Chronic Inflammation of the Gastrointestinal tract: The Dark Side of a Lipid Nuclear Receptor
5:15 pm
Karsten-Henrich Weylandt, M.D., Ph.D., Brandenburg Medical School, Germany
TBA
SESSION VI: GI TRACT (COLON, LIVER, PANCREAS) AND OTHER TISSUES – INFLAMMATION/METABOLIC
Co-Chairs:
Guodong Zhang, Ph.D., University of Massachusetts, Amherst, MA
Tara M. Nordgren, Ph.D., University of California, Riverside, CA
4:00 pm
Tara M. Nordgren, Ph.D., University of California, Riverside, CA
Maresin-1-mediated Protection from Dust-induced Lung Inflammation is Associated with Enhanced Macrophage IL-22 Signaling
4:25 pm
Guodong Zhang, Ph.D., University of Massachusetts, Amherst, MA
Soluble Epoxide Hydrolase is an Endogenous Regulator of Obesity-induced Intestinal Barrier Dysfunction and Bacterial Translocation
4:50 pm
Imad Shureiqi, M.D., University of Texas MD Anderson Cancer Center, Houston, TX
PPARD, Metabolism and Chronic Inflammation of the Gastrointestinal tract: The Dark Side of a Lipid Nuclear Receptor
5:15 pm
Karsten-Henrich Weylandt, M.D., Ph.D., Brandenburg Medical School, Germany
TBA
ORAL PRESENTATIONS
Location: Maryland Ballroom – D
SESSION VII: EICOSANOIDS AND HEART FAILURE
Co-Chairs:
Sachin A. Gupte, M.D., Ph.D., New York Medical College
John M. Seubert, MSc, PhD, University of Alberta, Edmonton, Alberta, Canada
8:30 am
John M. Seubert, MSc, PhD, University of Alberta, Edmonton, Alberta, Canada
Does Targeting Soluble Epoxide Hydrolase Preserve Cardiac and Mitochondrial Function in Aged Females?
8:55 am
Nipavan Chiamvimonvat, MD, University of California-Davis, Davis, CA
Beneficial Effects of Soluble Epoxide Hydrolase Inhibitors in Heart Failure: Molecular and Cellular Mechanisms
9:20 am
Petra Rocic, Ph.D., New York Medical College, Valhalla, NY
20-HETE and Ischemic Cardiomyopathy
9:45 am
Ilaria D’agostino, “G. d’Annunzio” University, Chieti, Italy
Low-dose Aspirin Protects against Elevated Blood Pressure and Cardiac Fibrosis in Mice
10:00 am
Coffee Break (20 min)
SESSION VIII: EICOSANOIDS AND THE OCULARS
Co-Chairs:
Ingrid Fleming, Ph.D., Institute for Vascular Signaling, Goethe University, Frankfurt, Germany
Kip M. Connor, Ph.D., Massachusetts Eye & Ear Infirmary/Harvard, Boston, MA
10:20 am
Kip M. Connor, Ph.D., Massachusetts Eye & Ear Infirmary/Harvard, Boston, MA
Therapeutic potential of bioactive lipids in neovascular AMD or Cytochrome P450 eicosanoids regulate choroidal neovascularization
10:45 am
Nicolas G. Bazan, MD, PhD, Louisiana State University Health, School of Medicine, New Orleans, LA
Bioactivity and Significance of the Novel Elovanoids of Retina Function and Retinal Degenerative Diseases
11:10 am
presentation to be chosen from the abstracts
TBA
11:25 pm
Ingrid Fleming, Ph.D., Goethe University, Frankfurt am Main, Germany
Sola dosis facit venenum: 19,20-Dihydroxydocosapentaenoic Acid and the Retinal Vasculature
11:50 pm
Lunch Break (1 hr, 30 min)
SESSION IX: EICOSANOIDS AND THE VASCULATURE
Co-Chairs:
Victor A. Garcia, Ph.D., New York Medical College Richard Roman, Ph.D. University of Mississippi, Jackson, MS
1:20 pm
Fan Fan, M.Dl, M.S., FAHA, University of Mississippi Medical Center, Jackson, MS
Role of 20-HETE in Alzheimer’s Disease-Related Dementias
1:45 pm
Anthony P. Barnes, Ph.D., Knight Cardiovascular Institute, Portland, OR
Regulation of Vascular Smooth Muscle Cell Signaling by the Eicosanoid-sensing Receptor GPR39
2:10 pm
William B. Campbell, Ph.D., Medical College of Wisconsin, Milwaukee, WI
TBA
2:35 pm
Victor A. Garcia, PhD, New York Medical College, Valhalla, NY
Macrophage 12(S)-HETE Enhances Angiotensin II-Induced Contraction through an AT2 and BLT2 Receptor-Mediated Isothromboxane Release in Murine Aortas
3:00 pm
Coffee Break (20 min)
JOHN C. MCGIFF MEMORIAL LECTURE
3:20 pm
William B. Campbell, Ph.D., Medical College of Wisconsin, Milwaukee, WI
Introduction of Awardee & Presentation
3:30 pm
Michal L. Schwartzman, Ph.D., New York Medical College
TBA